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The delicate-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence using a various sequence alignment (MSA) provided inside the seqAn library [27]. Wham applies a few filters into the consensus sequences. Breakpoints are usually not noted in conditions exactly where consensus sequences are shorter than ten bp

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Wham is made for paired-stop Illumina libraries with normal insert sizes (~300bp-500bp). Wham integrates mate-pair mapping, break up read through mapping, comfortable-clipping, alternate alignment and consensus sequence centered evidence to forecast SV breakpoints with single-nucleotide precision. Wham generates a blended pileup (catalog of reads m

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